I hope you are well and enjoying the start of spring. We have been very busy at Kingsway over the last few months. As a result, there has been an influx of new products. So I thought I would take this opportunity to fill you in.

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Vitamin B12 plays a key role in the normal functioning of the brain and nervous system, along with the formation of blood. It is normally involved in the metabolism of every cell of the body, especially affecting the DNA synthesis and regulation but also fatty acid synthesis and energy production.

Vitamin B12 is unique among the vitamins because it contains a metal ion (cobalt) located in the center of its activity. For this reason cobalamin is the term used when referring to compounds having B12 activity. Methylcobalamin and 5-dexoyadenosyl cobalamin (also known as adenosylcobalamin) are the forms of vitamin B12 used in the human body. Many commercial supplements on the market use cyanocobalamin; this form of vitamin B12 needs to be converted by the body to methylcobalamin or adenosylcobalamin.

Methylcobalamin is vital for the functioning of a folate-dependent enzyme known as methionine synthase. This enzyme is essential for the conversion of homocysteine to methionine (an area of great concern in autism and cardiovascular disease, among other conditions). Methionine is an amino acid which is required for the synthesis of S-adenosylmethionine (SAMe); a methyl group donor used in many biological methylation reactions.

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Kingsway Compounding is pleased to officially announce the addition of a dedicated sterile compounding room to its state of the art compounding laboratory at Brookvale. We now have the ability to compound sterile pharmaceuticals such as eye drops, eye ointments, injections and infusions.

The sterile compounding room has been through a full certification process and we have fully trained staff on site making up the sterile compounds. This is to ensure the highest standard of quality, which you have grown to trust and expect.

Kingsway Compounding is now also making up Methylcobalamin (Methyl B12) injections as per Jim Neubrander’s protocol. Following 12 months of extensive research and development, we released our first batches in March of this year and are very confident we have a stable, potent and efficacious product.

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Biotin is a water soluble vitamin, generally classified as a B-complex vitamin and is required by all organisms. It is obtained from food however most foods are poor sources of biotin, so a low intake is common (exceptions are biotin-rich foods such as egg yolk, kidney, liver and some cheeses). Scientists have also discovered that a portion of the biotin we use comes from the intestinal flora (such as E coli and bifidobacteria) found in a healthy human gut.

Biotin deficiency was once thought to be rare because such small amounts are required and clinical signs of deficiency are non-specific. However, recent findings are shifting the clinical outlook for biotin deficiency.

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Fructose malabsorption is a gastro-intestinal disorder, characterized by the inability to absorb fructose efficiently. As a consequence fructose reaches the colon where it is broken down by bacteria into short chain fatty acids, CO2, lactic acid, CH4 (methane) and H2 (hydrogen). This will usually induce bloating, cramps, osmotic diarrhea along with other symptoms of irritable bowel syndrome and can be seen in about 50% of fructose malabsorbers.

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This week I am going to discuss Hypochlorhydria – a condition where there is a lack of adequate stomach acid, i.e. hydrochloric acid (HCl) being secreted into the stomach.

Hypochlorhydria can lead to many health issues. Food that is not broken down moves from the stomach, into the small intestine and colon, and then exits the body unutilised. High acid levels are required for the break down of many trace minerals such as zinc, iron, copper, magnesium, calcium, boron, selenium, and vitamins B12 and B3.

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This week I am going to discuss a syndrome which is associated with abnormal intestinal permeability; commonly referred to as Leaky Gut Syndrome.

Leaky Gut Syndrome is a condition that is seen when the walls of the small intestine are damaged. A healthy intestine allows only nutrients to pass into the bloodstream. However, when the gut wall is damaged, larger molecules such as incompletely digested fats, proteins, starches, and even bacteria, also permeate the intestinal wall.

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This week I am going to discuss Vitamin D. This fat soluble compound exists in many forms however the form utilized primarily by humans is vitamin D3 (cholecalciferol).

Vitamin D is a regulator of calcium and phosphorus status; both of which are vital for normal functioning of the nervous system, as well as for bone growth and density. Vitamin D deficiency has been associated with cancer, cardiovascular disease, diabetes, autism and asthma, among other conditions (see below for more information). Evidence has shown that vitamin D is not stored in our bodies until a level of 50ng/ml is reached, which is why at Kingsway we recommend that patients use a starting dose of 50,000IU daily for three days, and then drop back to a maintenance dose of 4000-5000IU daily.

Animals (including humans) convert cholesterol to 7-dehydrocholesterol, which is a precursor to vitamin D3. Exposure to ultra violet light in sunlight (UVB radiation) converts 7-dehydrocholesterol in the skin to vitamin D3. In fact, adequate exposure to sunlight can eliminate the requirement for vitamin D in the diet, making it only “conditionally essential.” Vitamin D3 is not itself biologically active, but must be modified by the body to have any physiological effects.

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This week I am going to discuss Vitamin A; an antioxidant and general immune enhancer (specific against measles), which is commonly known as the “anti-infective vitamin.”

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I hope you had a lovely Christmas and a relaxing break. Our first newsletter for 2010 is going to look at one of our more popular supplements… Calcium / Magnesium. They are both classified as “essential minerals” which humans require for good health. Like all minerals, Calcium and Magnesium cannot be made in our body and must therefore be plentiful in our diet in order for us to remain healthy.

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Learning how to swallow capsules (or tablets) can be very challenging for children, as well as for some adults. We teach children not to swallow anything until it has been completely chewed and not to put strange objects in their mouths; so it is only natural that they find it difficult to swallow a capsule. Also some people have narrow throats, sensitive palates or a very strong “gag reflex”, which can initially make swallowing larger objects uncomfortable.

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One of the hardest tasks a parent has is to give their children medicines. Children hide, run, struggle or even fight back physically when it’s time for their medication. As a result, many parents have to resort to force, threats and bribery to ensure their kids take their prescriptions

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A normally functioning gastro-intestinal (GI) tract is an often overlooked important part of good health. The GI tract is responsible for the digestion and absorption of nutrient and fluid as well as protection from absorption of harmful agents. When the GI tract is not well, we can feel quite miserable with stomachache, vomiting, diarrhea or other symptoms, such as behavioral changes or problem behaviors. When healthy it seems to almost go unnoticed. However, it may not call attention to itself even when it is not functioning.

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Welcome to our first newsletter of 2009! My name is Eliza Tulloch (Elly) and I will be taking over from Karl in keeping you up-to-date with everything going on at Kingsway Compounding, as well as any new or interesting topics/products within the biomedical field. I am a qualified Nutritionist and Food Technologist, have strong familiarity and experience of the DAN and Pfeiffer treatment protocols, and am a PCCA Trained Compound Technician.

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