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Biotin is a water soluble vitamin, generally classified as a B-complex vitamin and is required by all organisms. It is obtained from food however most foods are poor sources of biotin, so a low intake is common (exceptions are biotin-rich foods such as egg yolk, kidney, liver and some cheeses).
This article discusses the connection between our gut and the immune system, and the importance of maintaining a healthy gut for a strong immune system
The MTHFR enzyme enables the correct metabolism of folate (vitamin B9), it converts 5,10-methylene-tetrahydrofolate to 5-methyl-tetrahydrofoate (5-MTHF).